Andy Carroll will be rested for West Ham's Carabao Cup third-round tie at home to Bolton on Tuesday evening.
Slaven Bilic will be looking to build on West Ham's 2-0 victory over Huddersfield when they visit West Bromwich Albion.
West Ham will finally play their first home game of the season as Huddersfield travel to the London Stadium for Monday Night Football.
West Ham manager Slaven Bilic has confirmed he is unlikely to risk winger Michail Antonio in the Carabao Cup tie at Sky Bet League Two side Cheltenham on Wednesday night.
Southampton's record signing Mario Lemina could start against West Ham on Saturday, but Virgil van Dijk will not be considered for selection.
Jose Mourinho has no fresh injury concerns heading into Manchester United's Premier League opener against West Ham, live on Sky Sports.
Burnley will look to put a gloss on what's been successful Premier League season when they host West Ham United on Sunday.
West Ham striker Andy Carroll is set to miss out against his former club Liverpool on Super Sunday after failing to recover in time from a groin injury, while Mark Noble is also absent.
Mauricio Pochettino has urged Tottenham Hotspur to beat West Ham United on Friday evening in order to put pressure on leaders Chelsea in the race for the Premier League.
Romelu Lukaku will be looking to score for the 10th game in a row against West Ham when Everton travel to the London Stadium on Saturday.