Stoke will have their sights set on passing the 40-point mark when they face West Ham on Saturday.
Aston Villa will be looking to end their seven-game Premier League winless run against West Ham.
West Ham are without top scorer Carlton Cole as they aim to boost their European push against Sunderland.
Another chapter in the battle to avoid the drop and the race for Europe will be written when Blackburn host West Ham.
West Ham will be looking to push West Brom closer to the drop when they meet on Monday night.
Craig Bellamy returns to Upton Park as Manchester City take on West Ham in Sunday's Premier League clash.
Middlesbrough hope an FA Cup fifth-round replay at home to West Ham will provide some respite.
Middlesbrough will look to defy their recent poor form when they face West Ham in the FA Cup fifth round.
The fifth round of the FA Cup traditionally separates those that can and those that dream as the competition really hots up.
Manchester United travel to West Ham looking to extend their record-breaking run in the league.